Selected List of recent publications

Haron-Khun S, Weisbrod D, Bueno H, Yadin D, Behar J, Peretz A, Binah O, Hochhauser E, Eldar M, Yaniv Y, Arad M and Attali B. (2017) SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias. EMBO Mol Med. 4: 415-429. [PDF]

Tobelaim WS, Dvir M, Lebel G, Cui M, Buki T, Peretz A, Marom M, Haitin Y, Logothetis DE, Hirsch JA, Attali B. (2017) Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel. Proc Natl Acad Sci U S A. 114 (5):E869-E878. [PDF]

Strulovich R, et al. (2016) Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex. Biochemistry 55 (38): 5353–5365. [PDF]

Patrich E, et al. (2016) Maternal immune activation produces neonatal excitability defects in offspring hippocampal neurons from pregnant rats treated with poly I:C.  Sci. Rep 6, doi: 10.1038/srep19106. [PDF]

Patrich E, et al. (2015) Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model. Brain Behav Immun 51:240-251. [PDF]

Sachyani D, et al. (2014) Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular C-Terminal domain in complex with calmodulin. Structure 22: 1582–1594. [PDF]

Dvir M, et al. (2014) Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt IKS regulation by PKA and PIP2. J Cell Sci. 127(Pt 18):3943-55. [PDF]

Dvir M, et al. (2014) Recent molecular insights from mutated IKS channels in cardiac arrhythmia. Curr Opin Pharmacol 15:74-82. [PDF]

Kornilov P, et al. (2014) Promiscuous gating modifiers target the voltage sensor of K(v)7.2, TRPV1, and H(v)1 cation channels. FASEB J. 28(6):2591-602. [PDF]

Kornilov P, et al. (2013) Channel gating pore: a new therapeutic target. Cell Res 23(9):1067-8. [PDF]

Weisbrod D, et al. (2013) SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 110(18):E1685-94. [PDF]

Meisel E, et al. (2012) KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein. J Biol Chem 287(41):34212-24. [PDF]

Gofman Y, et al. (2012) How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex. Structure 20(8):1343-52. [PDF]

Ebner-Bennatan S, et al. (2012) Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ε tunes neuronal excitability. J Biol Chem 287(33):27614-28. [PDF] 

Strutz-Seebohm N, et al. (2011) Structural basis of slow activation gating in the cardiac I Ks channel complex. Cell Physiol Biochem 27(5):443-452. [PDF]

Peretz A, et al. (2010) Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier. Proc Natl Acad Sci U S A 107(35):15637-15642. [PDF]

Haitin Y, et al. (2009) Intracellular domains interactions and gated motions of I(KS) potassium channel subunits. EMBO J 28(14):1994-2005. [PDF]

Haitin Y, et al. (2008) S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels. PLoS One 3(4):e1935. [PDF]

Seebohm G, et al. (2008) Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels. Circ Res 103(12):1451-1457. [PDF]

Shamgar L, et al. (2008) KCNE1 constrains the voltage sensor of Kv7.1 K+ channels. PLoS One 3(4):e1943. [PDF]

Wiener R, et al. (2008) The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J Biol Chem 283(9):5815-5830. [PDF]

Gibor G, et al. (2007) An inactivation gate in the selectivity filter of KCNQ1 potassium channels. Biophys J 93(12):4159-4172. [PDF]

Peretz A, et al. (2007a) A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives. PLoS One 2(12):e1332. [PDF]

Peretz A, et al. (2007b) Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release. J Neurophysiol 97(1):283-295. [PDF]

Seebohm G, et al. (2007) Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res 100(5):686-692. [PDF]

Shamgar L, et al. (2006) Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations. Circ Res 98(8):1055-1063. [PDF]

Tiran Z, et al. (2006) Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells. Mol Biol Cell 17(10):4330-4342. [PDF]

Paas Y, et al. (2005) Pore conformations and gating mechanism of a Cys-loop receptor. Proc Natl Acad Sci U S A 102(44):15877-15882. [PDF]

Peretz A, et al. (2005) Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 67(4):1053-1066. [PDF]

Gibor G, Yakubovich D, Peretz A, & Attali B (2004) External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol 124(1):83-102. [PDF]

Toledo-Rodriguez M, et al. (2004) Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex. Cereb Cortex 14(12):1310-1327. [PDF]

Tiran Z, Peretz A, Attali B, & Elson A (2003) Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. J Biol Chem 278(19):17509-17514. [PDF]

Peretz A, Schottelndreier H, Aharon-Shamgar LB, & Attali B (2002) Modulation of homomeric and heteromeric KCNQ1 channels by external acidification. J Physiol 545(Pt 3):751-766. [PDF]

Desai R, Peretz A, Idelson H, Lazarovici P, & Attali B (2000) Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. J Biol Chem 275(51):39954-39963. [PDF]

Levite M, et al. (2000) Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins. J Exp Med 191(7):1167-1176. [PDF]

Peretz A, et al. (2000) Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J 19(15):4036-4045. [PDF]

Schmitt N, et al. (2000) A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J 19(3):332-340. [PDF]

Abitbol I, Peretz A, Lerche C, Busch AE, & Attali B (1999) Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants. EMBO J 18(15):4137-4148. [PDF]

Peretz A, Sobko A, & Attali B (1999) Tyrosine kinases modulate K+ channel gating in mouse Schwann cells. J Physiol 519 Pt 2:373-384. [PDF]

Peretz A, Abitbol I, Sobko A, Wu CF, & Attali B (1998) A Ca2+/calmodulin-dependent protein kinase modulates Drosophila photoreceptor K+ currents: a role in shaping the photoreceptor potential. J Neurosci 18(22):9153-9162. [PDF]

Sobko A, Peretz A, & Attali B (1998a) Constitutive activation of delayed-rectifier potassium channels by a src family tyrosine kinase in Schwann cells. EMBO J 17(16):4723-4734. [PDF]

Sobko A, et al. (1998b) Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. J Neurosci 18(24):10398-10408. [PDF]