Closed and open state models of Kv7.1 channel and its auxiliary subunit KCNE1

Co-immunostaining of Kv7.2 channels and presynaptic V-Glut1 in hippocampal neurons

Docking of NH29 onto a model structure of Kv7.2 channel in an open state

Co-immunostaining of Kv7.2 channels and presynaptic GAD65 in hippocampal neurons

Structural models of wild-type and pore mutants of Kv7.1 channels

The research laboratory of Bernard Attali

Structure, biophysics and physiology of normal and diseased potassium channels in brain and heart

Potassium channels are essential for life. They are key players of many vital functions as diverse as those of the heart, brain, muscle, kidney, pancreas or immune system. Members of the Kv7 family of voltage-gated potassium channels play a major role in modulating brain and cardiac excitability. Consistent with their physiological importance, mutations in human Kv7 genes lead to severe inherited cardiovascular and neurological disorders such as cardiac arrhythmia, neonatal epilepsy and deafness. Our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased Kv7 channel proteins in brain and heart. Read More »